Lifeboat Foundation

Deeply fascinating paper wherein Venkataramani et al. describe how synaptic inputs from neurons onto glioma tumor cells induce electrical activity in the tumors and stimulate their growth and invasiveness. This knowledge could lead to new treatments involving inhibition of the synapses onto gliomas which might provide hope for fighting an otherwise largely incurable form of cancer. #neurobiology #oncology #cancer #medicine

Neurons form glutamatergic synapses with glioma cells in mice and humans, and inhibition of AMPA receptors reduces glioma cell invasion and growth.

A man paralyzed by a cycling accident is able to walk again after an experimental operation by neuroscientists and surgeons in Switzerland.

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Continue reading “Paralyzed man walks after bluetooth connects his brain and spine” »

The psychedelic substances 5-MeO-DMT causes a long-lasting increase in the number of tiny protrusions called dendritic spines in the brain, according to new research published in Neuropsychopharmacology. The study, which was conducted on mice, sheds light on the behavioral and neural mechanisms of 5-MeO-DMT.

Serotonergic psychedelics (such as psilocybin and LSD) have shown promise as potential therapeutics for mental illnesses like depression and anxiety. Short-acting compounds are particularly interesting because they require less dosing time, which could improve patient access to treatment. In humans, 5-MeO-DMT produces a short-lasting experience due to its rapid breakdown in the body.

“My lab started research on psychiatric drugs like ketamine and psychedelics about 10 years ago. We were motivated by how basic science and clinical research can together powerfully move a drug forward to become medicine. Specifically I believe there is a lot of potential for psychedelics as therapeutics, and that drives our interest in this topic,” said study author Alex Kwan (@kwanalexc), an associate professor in the Meinig School of Biomedical Engineering at Cornell University.

The startup tested its technology on primates for several years.

Language models similar to ChatGPT have started to transform neuroscience.

The billionaire’s Neuralink implant company wants to help restore people’s vision and mobility.

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Neuralink, Elon Musk’s brain-implant company, said on Thursday it had received a green light from the US Food and Drug Administration (FDA) to kickstart its first in-human clinical study, a critical milestone after earlier struggles to gain approval.

Musk has predicted on at least four occasions since 2019 that his medical device company would begin human trials for a brain implant to treat severe conditions such as paralysis and blindness.

Continue reading “Elon Musk’s brain implant company Neuralink approved for in-human study” »

Implanted brain electrodes send signals that bypass damaged spinal cord area, using man’s thoughts to stimulate leg movement.

Scientists have found a way to restore the brain and spinal cord interface, developing an implantable device that enables paralyzed patient to stand and walk again.

A spinal cord injury (SCI) can be debilitating for some people, making it difficult for them to walk normally again. Some individuals may take weeks to recover their ability to walk after an injury, while others may take months or even suffer from paralysis.

This is mainly due to the SCI hindering communication between the brain and the region of the spinal cord responsible for limb movement.