Lifeboat Foundation

Age-related hearing loss impacts one in three adults between the ages of 64 and 75 in the US, and around half of these numbers are down to genes.

The extra kicker, though, is that because hearing involves a complex genetic toolkit, it also makes this kind of hearing loss incredibly difficult to treat.

A team of researchers has for the first time targeted age-related genetic hearing loss in a much older cohort of mice, which had a mutation of the human transmembrane serine protease 3 (TMPRSS3) gene that results in autosomal recessive deafness 8/10 (DFNB8/DFNB10).

Glioblastoma Multiforme (GBM) is the most aggressive and most common primary malignant brain tumor. The age of GBM patients is considered as one of the disease’s negative prognostic factors and the mean age of diagnosis is 62 years. A promising approach to preventing both GBM and aging is to identify new potential therapeutic targets that are associated with both conditions as concurrent drivers. In this work, we present a multi-angled approach of identifying targets, which takes into account not only the disease-related genes but also the ones important in aging. For this purpose, we developed three strategies of target identification using the results of correlation analysis augmented with survival data, differences in expression levels and previously published information of aging-related genes.

I quoted and responded to this remark:

“…we probably will not solve death and this actually shouldn’t be our goal.” Well nice as she seems thank goods Dr Levine does not run the scientific community involved in rejuvenation.

Continue reading “The science of super longevity | Dr. Morgan Levine” »

In short blood dilution is very, very good for you.

In this talk, Dr. Irina Conboy discusses the role of repair and regeneration in lifespan and healthspan, contending that these factors, rather than entropy and time progression, truly govern our aging process. She describes the research her team is pursuing, investigating whether improving the efficiency of bodily repair in older individuals could effectively make them younger. She suggests that biological age could potentially be reversed and discusses heterochronic parabiosis and plasma dilution as potential ways to accomplish that. Conboy highlights recent research suggesting that old blood has a greater impact on cellular health and function than young blood. She presents her team’s experimental research on the rejuvenation effects of plasma dilution, demonstrating its significant impact on reducing senescence, neuroinflammation, and promoting neurogenesis in the brains of old mice.

Continue reading “Decoding the Aging Process: The Impact of Blood Dilution on Biological Age (Irina Conboy at EARD)” »

Year 2022 This new protein Newtic1 holds promise to fully understanding limb regeneration in humans. Still though genetic engineering will be needed to fully integrate the ability for limb and body part regeneration.

The animal kingdom exhibits a plethora of unique and surprising phenomena or abilities that include, for some animals, the ability to regenerate body parts irrespective of age. Now, researchers from Japan have discovered that the mechanisms behind this peculiar ability in newts have a few surprises of their own.

The Forever Healthy Foundation is pleased to announce the second edition of the Rejuvenation Startup Summit, following the inaugural Rejuvenation Startup Summit in 2022 with more than 400 participants from over 30 countries. It will take place on 10–11 May 2024 in Berlin. The Rejuvenation Startup Summit is the world’s largest in-person gathering of longevity startups. It brings together startups, members of the longevity venture capital / investor ecosystem, and researchers interested in starting or joining a startup – all with the goal of accelerating the development of the rejuvenation biotech industry.

At Blueprint we’ve explored and evaluated hundreds of anti-aging therapies.

Recently, we had a daring idea: what if my father, son and I completed the world’s first ever multi-generational plasma exchange?

Continue reading “Will My Son’s Blood Make Me Younger?” »

A new protein discovery may have highlighted a ‘switch’ in brain cells that slows down inflammation and aging.

Lifespan by simply slowing the aging of an organ, such as the intestine? CNRS researchers have discovered how to extend the life expectancy of zebrafish by reactivating a gene within intestinal cells. The results were published in the journal Nature Aging on May 4, 2023.

The intestine plays a crucial role in an anti-aging approach as well as general health. Over a century ago, Elie Metchnikov observed that aging ensued from increased inflammation of the intestine and microbial infiltration within blood circulation. The more we age, the less the digestive tract serves as a barrier, allowing the undesirable particles and bacteria that cause the more rapid aging of the organism to pass through.

In a new study, Miguel Godinho Ferreira and his team at the Institute for Research on Cancer and Aging (Ircan) in Nice (CNRS/Inserm/Université Côte d’Azur) have studied the impact on aging of telomere length in the intestinal cells of zebrafish. As with humans, these chromosome extremities shrink faster in the intestine than in other organs during the course of a life, which is why this process plays such an important role in aging.