How we’re linking together genetic material from thousands of people — modern and ancient — to trace our ancestors and the history of our evolution.
A new study published on eLife and led by the Institute for Evolutionary Biology (IBE, CSIC-UPF) and the IRB Barcelona, has revealed that the Chinmo gene is responsible for establishing the juvenile stage in insects. It also confirms that the Br-C and E93 genes play a regulatory role in insect maturity. These genes, which are also present in humans, act as a promoter and as a suppressor, respectively, of cancerous processes.
The results of the research, which was carried out with the fruit fly Drosophila melanogaster and the cockroach Blatella germanica, reveal that these genes have been conserved throughout the evolution of insects. Therefore, it is believed that they could play a key role in the evolution of metamorphosis.
Insects that undergo complete metamorphosis, such as flies, go through the following three stages of development: the embryo, which is formed inside the egg; the larva (juvenile stage), which grows in several phases; and the pupa, which is the stage that encompasses metamorphosis and the formation of the adult organism.
New model for human evolution suggests Homo sapiens arose from multiple closely related populations.
A new study in Nature challenges prevailing theories, suggesting that Homo sapiens evolved from multiple diverse populations across Africa, with the earliest detectable split occurring 120,000–135,000 years ago, after prolonged periods of genetic intermixing.
In testing the genetic material of current populations in Africa and comparing it against existing fossil evidence of early Homo sapiens populations there, researchers have uncovered a new model of human evolution — overturning previous beliefs that a single African population gave rise to all humans. The new research was published on May 17, in the journal Nature.
At Blueprint we’ve explored and evaluated hundreds of anti-aging therapies.
Recently, we had a daring idea: what if my father, son and I completed the world’s first ever multi-generational plasma exchange?
Ago when I was a kid in college my friend Eric got me into many things. We played music together and used a Kurzweil Keyboard, and a bunch of weird stuff. We had an ADAT hooked up to the Kurzweil with fiber optic cables. I had Roland keyboards & Drum machines but I loved the Kurzweil. He started teaching me many things because he was really smart. I was studying psychology so he loaned me his DSMIV and books on Industrial Organiza… See more.
A bit long, but a good read. About 20 years ago when I was a kid in college my friend Eric got me into many things. We played music together and used a Kurzweil Keyboard, and a bunch of weird stuff. We had an ADAT hooked up to the Kurzweil with fiber optic cables. I had Roland keyboards & Drum machines but I loved the Kurzweil. He started teaching me many things because he was really smart. I was studying psychology so he loaned me his DSMIV and books on Industrial Organizational Psychology. He then told me about other books like “Society of Mind”(Marvin Minsky), “Age of Intelligent Machine” (Ray Kurzweil), Engines of Creation (K Eric Drexler), of course Richard Feynman, and many more. I dreamed of that technology and kept reading more. In the 2000’s Drexler and Feynman’s visions became a paradign and applications started rolling out, and now nanotechnology is applied to most everything we know. We are now at the second paradigm where we see the visions of Minsky/McCarthy, Kurzweil and others becoming easily available applications. As a Child I watched the Jetsons & Srar Trek and now with flying cars it’s not if, but when. Space travel is already here. All these technologies will transform global societies, but we must all focus on investing more in the advancement of society than the destruction of it. Many of the things we now invision in our minds we may see in 10 years. People think saving your consciousness & longevity is impossible, but I don’t. Some even thought that regenerating tissue and organs is impossible, but we can do that now. Now people keep saying, “This ancient turtle died, this rhino died (I hear that all the time in Kenya), this elephant died, but I say okay it’s not cool, but what can we salvage from it to bring the species back with advances in technology later? Do we use cryogenics? How do we save the genetic material? Technology can be used in so many ways. Every Day Lifeboat posts feats many do not know. If more people on earth had such a focus, as opposed to dumbed down entertainment like The Kardashians for instance, we would be living in a much better world with more people proposing more ideas and collaborations. I always say we are moving in the wrong way in the evolutionary process, and it is a bit telling that some phones are smarter than many people. I you add ChatGPT. We have so much advanced technology and science, yet we can’t even fight cancer. It took decades for people to learn the importance of diet in HIV treatment. However, Ray Kurzweil has for decades talked about the importance of diet for longevity. Just the other day it was published that processed foods affect cognitive function. Before that it was released processed foods cause cancer. We must change, and go in the right way of evolution to the Singularity another paradigm shift and cooperarion, instead of backwards to a barbaric age of conflict and greed. Always share your knowledge and I thank all who do share in this group. More should share as well, and Lifeboat should use more platforms to reach more people.
Scientists have announced that the oldest living creature on our planet is a jellyfish-like organism called a ctenophore. It evolved from the same primordial animals that humans did.
This fascinating creature first emerged 700 million years ago, a significant time before the dinosaurs, which appeared only 230 million years ago. The study found that ctenophores are the closest relatives of the first animals and can still be spotted in modern-day oceans and aquariums.
A team from the University of California, Berkeley embarked on a quest to decipher the relationships within the animal tree of life. They wanted to broaden our understanding of the origins and evolution of life on Earth.
As sponges and ctenophores are such disparate animals13, the nature of the first diverging animal lineage has implications for the evolution of fundamental animal characteristics. Adult sponges are generally sessile filter-feeding organisms with body plans organized into reticulated water-filtration channels, structures built out of silica or calcium carbonate, and specialized cell types and tissues used for feeding, reproduction and self-defence, but they lack neuronal and muscle cells15. By contrast, ctenophores are gelatinous marine predators that move using eight longitudinal ‘comb rows’ of ciliary bundles16,17; they are superficially similar but unrelated to cnidarian medusae13,18 and possess multiple nerve nets19. Thus, whereas the sponge-sister scenario suggests a single origin of neurons on the ctenophore–parahoxozoan stem, the ctenophore-sister scenario implies either that either ancestral metazoan neurons were lost in the sponge lineage, or that there was convergent evolution of neurons in the ctenophore and parahoxozoan lineages3,6. Similar considerations apply to other metazoan cell types18, gene regulatory networks, animal development13,18 and other uniquely metazoan features.
Despite its importance for understanding animal evolution, the relative branching order of sponges, ctenophores and other animals has proven to be difficult to resolve2. The fossil record is largely silent on this issue as verified Precambrian sponge fossils are extremely rare20 and putative fossils of the soft-bodied ctenophores are difficult to interpret21. Morphological characters of living groups (for example, choanocytes of sponges) are not sufficient to resolve the question because true homology is difficult to assign, and such characters are easily lost or can arise convergently13,22. The ctenophore-sister hypothesis is supported by a pair of gene duplications shared by sponges, bilaterians, placozoans and cnidarians but not ctenophores23. Although sophisticated methods for sequence-based phylogenomics have been developed and applied to increasingly large molecular datasets, there is still considerable debate about the relative position of sponges and ctenophores as results are sensitive to how sequence evolution is modelled11, which taxa or sites are included24,25, and the effects of long-branch artifacts and nucleotide compositional variation26. New approaches are needed.
We reasoned that patterns of synteny, classically defined as chromosomal gene linkage without regard to gene order27, could provide a powerful tool for resolving the ctenophore-sister versus sponge-sister debate. Chromosomal patterns of gene linkage evolve slowly in many lineages12,28,29,30, probably because it is improbable for interchromosomal translocations to be fixed in populations with large effective population sizes28,31,32. Notably, some changes in synteny are effectively irreversible. For example, when two distinct ancestral synteny groups are combined onto a single chromosome by translocation, and subsequent intrachromosomal rearrangements mix these two groups of genes, it is very unlikely that the ancestral separated pattern will be restored by further rearrangement and fission, in the same sense that spontaneous reduction in entropy is improbable12. Such rare and irreversible changes are particularly useful for resolving challenging phylogenetic questions as they give rise to shared derived features that unambiguously unite all descendant lineages33,34,35. Deeply conserved syntenies observed between animals and their closest unicellular relatives12 suggest that outgroup comparisons could be used to infer ancestral metazoan states and polarize changes within animals to address the sponge-sister versus ctenophore-sister debate. Yet, chromosome-scale genome sequences of the unicellular or colonial eukaryotic outgroups closest to animals (choanoflagellates, filastereans and ichthyosporeans) have not been reported.
Dr. Steven Gazal, an assistant professor of population and public health sciences at the Keck School of Medicine of USC, is on a mission to answer a perplexing question: Why, despite millions of years of evolution, do humans still suffer from diseases?
As part of an international research team, Gazal has made a groundbreaking discovery. They’ve become the first to accurately pinpoint specific base pairs in the human genome that have remained unaltered throughout millions of years of mammalian evolution. These base pairs play a significant role in human disease. Their findings were published in a special Zoonomia edition of the journal Science.
Gazal and his team analyzed the genomes of 240 mammals, including humans, zooming in with unprecedented resolution to compare DNA.
Scientists with the Human Pangenome Reference Consortium have made groundbreaking progress in characterizing the fraction of human DNA that varies between individuals. They have assembled genomic sequences of 47 people from around the world into a so-called pangenome in which more than 99 percent of each sequence is rendered with high accuracy.
For two decades, scientists have relied on the human reference genome as a standard to compare against other genetic data. Thanks to this reference genome, it was possible to identify genes implicated in specific diseases and trace the evolution of human traits, among other things.
However, it has always been a flawed tool: 70% of its data came from a single man of predominantly African-European background whose DNA was sequenced during the Human Genome Project. Hence, it can reveal very little about individuals on this planet who are different from each other, creating an inherent bias in biomedical data believed to be responsible for some of the health disparities affecting patients today.
A spinning plasma ring mimics the rotating structure surrounding a black hole.
Astrophysicists have many questions about the so-called accretion disk that forms from plasma and other matter falling into a black hole. Now researchers have generated a rotating ring of plasma in an unconfined arrangement in the lab, which will enable more realistic studies of plasma in astrophysical disks [1]. The lab plasma also produced a jet perpendicular to the disk, as real black holes do. The experiment could provide a platform for testing theories describing the evolution of astrophysical disks.
According to observations, the matter in a black hole accretion disk spirals inward at a rate that is thousands of times faster than would be expected from turbulence-free rotation. The leading explanation involves turbulence generated in part by the interaction of magnetic fields with the plasma in the disk, but this theory is difficult to test without a lab plasma that rotates rapidly. Such an experimental system would also allow researchers to investigate accretion disks around massive objects other than black holes.
