Archive for the ‘cryonics’ category

Apr 27, 2023

Recent clinical trials with stem cells to slow or reverse normal aging processes

Posted by in categories: biotech/medical, cryonics, finance, life extension, nuclear energy

Stem cells (SCs) are undifferentiated cells which can proliferate indefinitely or differentiate into progenitor cells and end-phase differentiated cells (becoming pluripotent) (Mayo, 2021; Slack, 2022). Human embryonic SCs (hE-SCs) are found in the inner cell mass of the blastocyst; h E-SC research raises ethical concerns (Lo and Parham, 2009), and h E-SC transplantation in vivo can lead to the formation of large tumors called teratomas (Blum and Benvenisty, 2008).

Small numbers of adult SCs are found in some organ “niches”, including the bone marrow, where hematopoietic progenitor cells (HPC) replenish blood and immune cells. In 1958, Mathe et al. (1959) successfully performed the first adult SC therapy on five workers who had received high-dose accidental irradiation at the Vinca Nuclear Institute in Yugoslavia. After transfusions and grafts of homologous adult bone marrow, all workers survived (Mathe et al., 1959).

For years, the human umbilical cord was a waste material and, unlike h E-SCs, its use does not raise ethical concerns. In 1988, Gluckman et al. (1989) successfully performed the first human cord blood transplant in a child with Fanconi’s anemia. Since then, numerous public and private cord blood banks have been established worldwide for the cryopreservation of cord blood in view of its transplantation (Gluckman, 2011).

Apr 2, 2023

A Disease Reversal Therapy That No Body Try Before

Posted by in categories: biotech/medical, cryonics, genetics, life extension

Previously Fahy has reported as much as a 15 year epigenetic clock reset. Again though, this won’t get you beyond your maximum natural limit, but younger and healthier now leads to the next bridge.

Dr Greg Fahy talks about the thymus magic. What are the out of expectation benefits of reprogramming our thymus(Not TRIIM or TRIIM-X) in this short clip.

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Apr 1, 2023

The CryoPrize (The Organ Cryopreservation Prize)

Posted by in categories: biotech/medical, cryonics, life extension

PLEASE CLICK ON LINK TO DONATE: 3 Minute video detailing our efforts to make organ transplants safer, less costly and more available to those in need by offering a prize, beginning at $50,000, to the first person or group to successfully freeze, and restore to full function, one of several mammalian organs.

Mar 30, 2023

Transplantation of clinical-grade human neural stem cells reduces neuroinflammation, prolongs survival and delays disease progression in the SOD1 rats

Posted by in categories: biotech/medical, cryonics, life extension, neuroscience

The hNSCs used in the study have been produced and characterised in the Cell Factory and Biobank of Santa Maria Hospital (Terni, Italy), authorised by the Italian Medicine Agency (AIFA) for the production of hNSCs to be used for clinical trials (aM 54/2018). The methodology applied to isolate, expand, characterise and cryopreserve the lines is based on the Neurosphere Assay26,41,54, and has been used for the production of the cells utilised in phase I trials for Amyotrophic Lateral Sclerosis patients (NCT0164006723) and for Secondary Progressive Multiple Sclerosis patients (NCT03282760, ongoing).

The entire production process, starting from tissue procurement to cryopreservation is compliant to cGMP guidelines and approved by AIFA. The hNSCs are obtained from foetal brain tissue derived from fetuses that underwent miscarriage or natural in utero death upon receiving the signed informed consent from the mother. Forty-eight hours prior to implantation, hNSCs were plated in the growth medium at a concentration of 10,000 cells/cm2. On the day of surgery, hNSCs were collected by centrifugation, viable cells were counted by Trypan blue exclusion criteria, and the correct number of cells were re-suspended in HBSS for the transplant.

SOD1 transgenic male rats were randomly divided into three experimental groups: (i) transplanted with hNSCs (hNSC rats, n = 15); (ii) treated with HBSS (HBSS rats, n = 15) and (iii) untreated (CTRL rats, n = 22). An additional group of non-transgenic littermates (wild-type, WT, n = 9) were used as controls for symptomatic evaluation of the colony. Tacrolimus (FK506) and cyclosporine (cyclosporin A) are the principal immunosuppressive drugs that have been applied for solid organ transplantation55,56 and have been translated to stem cell treatments for PD57 and ALS22. In animal models, despite differences in potency, both drugs showed excellent survival rates for grafts across many comparative studies58,59. Our previous results44,45 showed that hNSCs can survive—without signs of rejection—in the rat brain up to 6 months under transient immunosuppression treatment, with cyclosporin A. On the bases of these results, we applied the same immunosuppressive treatment with administration of cyclosporine A (15 mg/kg/day subcutaneous; Sandimmne, Novartis) that was initiated on the day of transplantation and continued for 15 days after surgery (for all animal groups).

Mar 18, 2023

Tomorrow Biostasis: The Berlin Startup That Wants to Bring You Back from the Dead

Posted by in categories: biotech/medical, cryonics, life extension, neuroscience

What if death was not the end? What if, instead of saying our final goodbyes to loved ones, we could freeze their bodies and bring them back to life once medical technology has advanced enough to cure their fatal illnesses? This is the mission of Tomorrow Biostasis, a Berlin-based startup that specializes in cryopreservation.

Cryopreservation, also known as biostasis or cryonics, is the process of preserving a human body (or brain) in a state of suspended animation, with the hope that it can be revived in the future when medical technology has advanced enough to treat the original cause of death. This may seem like science fiction, but it is a legitimate scientific procedure, and Tomorrow Biostasis is one of the few companies in the world that offers this service.

Dr Emil Kendziorra, co-founder and CEO of Tomorrow Biostasis explained that the goal of cryopreservation is to extend life by preserving the body until a cure can be found for the original illness. He emphasized that cryopreservation is not a form of immortality, but rather a way to give people a second chance at life.

Jan 17, 2023

Inside the US facility that has cryofrozen 199 ‘patients’ and 100 pets

Posted by in categories: biotech/medical, cryonics, life extension

This American cryonics facility has preserved “patients” in liquid nitrogen-filled tanks until a future date when technology allows them to be thawed.

Jan 5, 2023

The Failures and Opportunities of Immortality | Peter Ward, Feedback Loop, ep 75

Posted by in categories: bioengineering, biotech/medical, business, cryonics, life extension, media & arts

This week our guest is business and technology reporter, Peter Ward. Earlier this year, Peter released his book The Price of Immortality: The Race to Live Forever, where he investigates the many movements and organizations that are seeking to extend human life, from the Church of Perpetual Life in Florida, to some of the biggest tech giants in Silicon Valley.

In this episode, we explore Peter’s findings, which takes us on a tour from cryonics to mind uploading, from supplements to gene editing, and much more. Along the way, we discuss the details of how one might actually achieve immortality, the details of senescent cells and telomeres, whether it’s better to live healthy than to live long, the scams and failures that seem to dominate the space, as well as the efforts that seem most promising.

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Dec 10, 2022

Why Cryonics Is a Good Option: More Time for Your Life

Posted by in categories: cryonics, life extension

Life is short, but Tomorrow Bio explains how cryonics is a good option that can offer more time for your lifespan. Check out how below!

Dec 5, 2022

Cryonics Institute Home

Posted by in categories: cryonics, life extension

You can arrange for automatic PayPal payment of Yearly Membership Dues on a Quarterly or Yearly basis AFTER you have filled-in and submitted a membership application and paid the initiation fee which have been received and approved. (You can pay the initiation fee by going to PayPal. From the top menu, select “Personal Send and receive Send Money.” Enter for the email address and make your payment of $75.) Note that when arranging for automatic Quarterly or Yearly payment, the first Quarterly or Yearly payment is made IMMEDIATELY upon arranging for automatic payment.

Dec 4, 2022

The Thymus As A Key Target For Aging Intervention — Dr. Greg Fahy — EARD 2022

Posted by in categories: biotech/medical, computing, cryonics, genetics, life extension

This is a followup trial result to the first trial that reported 2.5 years of epigenetic age reversal This has interesting reports from the actual patients about how they feel and the changes it made to them. After the first trial I sent an email to see if I could do this but I have IBS which Fahy said would disqualify me.

Dr. Greg Fahy gives an update on the TRIIM-X clinical trial at EARD 2022.

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