Lifeboat Foundation

Age-related hearing loss impacts one in three adults between the ages of 64 and 75 in the US, and around half of these numbers are down to genes.

The extra kicker, though, is that because hearing involves a complex genetic toolkit, it also makes this kind of hearing loss incredibly difficult to treat.

A team of researchers has for the first time targeted age-related genetic hearing loss in a much older cohort of mice, which had a mutation of the human transmembrane serine protease 3 (TMPRSS3) gene that results in autosomal recessive deafness 8/10 (DFNB8/DFNB10).

A breakthrough in fluorescence microscopy has been achieved by the research group of Ralf Jungmann at the Max Planck Institute of Biochemistry (MPIB) and Ludwig-Maximilians-Universität (LMU) Munich. The team developed Resolution Enhancement by Sequential Imaging (RESI), a revolutionary technique that enhances the resolution of fluorescence microscopy down to the Ångström scale. This innovation is poised to usher in a paradigm shift in our approach to study biological systems with thus far unprecedented detail.

Cells, the fundamental units of life, contain a plethora of intricate structures, processes and mechanisms that uphold and perpetuate living systems. Many cellular core components, such as DNA, RNA, proteins and lipids, are just a few nanometers in size. This makes them substantially smaller than the resolution limit of traditional light microscopy. The exact composition and arrangement of these molecules and structures is thus often unknown, resulting in a lack of mechanistic understanding of fundamental aspects of biology.

In recent years, super-resolution techniques have made leaps and bounds to resolve many sub-cellular structures below the classical diffraction limit of light. Single molecule localization microscopy, or SMLM, is a super-resolution approach that can resolve structures on the order of ten nanometers in size by temporally separating their individual fluorescence emission.

A man paralyzed by a cycling accident is able to walk again after an experimental operation by neuroscientists and surgeons in Switzerland.

Subscribe for more Breaking News: http://smarturl.it/AssociatedPress.
Website: https://apnews.com.
Twitter: https://twitter.com/AP
Facebook: https://facebook.com/APNews.
Instagram: https://www.instagram.com/APNews/

Continue reading “Paralyzed man walks after bluetooth connects his brain and spine” »

How we’re linking together genetic material from thousands of people — modern and ancient — to trace our ancestors and the history of our evolution.

Summary: A novel study uncovers a peculiar pattern of decision-making in mice, influenced by a specific gene named Arc.

While searching for food, mice repeatedly visited an empty location instead of staying at a site abundant in food. However, mice lacking the Arc gene demonstrated a more practical approach, sticking with the food-rich site, thereby consuming more calories overall.

This unique research potentially opens the door for a new field, ‘decision genetics’, investigating the genetic influence on decision-making, possibly even in humans.

In December 2022, founder Elon Musk gave an update on his other, other company, the brain implant startup Neuralink. As early as 2020, the company had been saying it was close to starting clinical trials of the implants, but the December update suggested those were still six months away. This time, it seems that the company was correct, as it now claims that the Food and Drug Administration (FDA) has given its approval for the start of human testing.

Neuralink is not ready to start recruiting test subjects, and there are no details about what the trials will entail. Searching the ClinicalTrials.gov database for “Neuralink” also turns up nothing. Typically, the initial trials are small and focused entirely on safety rather than effectiveness. Given that Neuralink is developing both brain implants and a surgical robot to do the implanting, there will be a lot that needs testing.

It’s likely that these will focus on the implants first, given that other implants have already been tested in humans, whereas an equivalent surgical robot has not.

Learn more about Dr. Hugo De Garis.
https://www.imdb.com/name/nm2433396/

CANADIAN PREPPERS SURVIVAL SUPERSTORE! Use discount code SURVIVALPREPPER for 10% off / Premium Survival/ Emergency Equipment.
https://canadianpreparedness.com/

Continue reading “He Predicted Chat GPT 40 years Ago… Now he Has a Warning” »

Glioblastoma Multiforme (GBM) is the most aggressive and most common primary malignant brain tumor. The age of GBM patients is considered as one of the disease’s negative prognostic factors and the mean age of diagnosis is 62 years. A promising approach to preventing both GBM and aging is to identify new potential therapeutic targets that are associated with both conditions as concurrent drivers. In this work, we present a multi-angled approach of identifying targets, which takes into account not only the disease-related genes but also the ones important in aging. For this purpose, we developed three strategies of target identification using the results of correlation analysis augmented with survival data, differences in expression levels and previously published information of aging-related genes.

A team of engineers at the University of Colorado Boulder has designed a new class of tiny, self-propelled robots that can zip through liquid at incredible speeds—and may one day even deliver prescription drugs to hard-to-reach places inside the human body.

The researchers describe their mini healthcare providers in a paper published last month in the journal Small.

“Imagine if microrobots could perform certain tasks in the body, such as non-invasive surgeries,” said Jin Lee, lead author of the study and a postdoctoral researcher in the Department of Chemical and Biological Engineering. “Instead of cutting into the patient, we can simply introduce the robots to the body through a pill or an injection, and they would perform the procedure themselves.”