Dr. Andres M. Lozano
The MedPage Today article Deep-Brain Stimulation Sparks a Patient’s Memory said
Vivid memories from 30 years earlier suddenly flooded back to a 50-year-old obese patient who was undergoing deep-brain stimulation of the hypothalamus to suppress appetite, researchers here reported.
Unexpectedly, three weeks of deep-brain stimulation significantly improved the patient’s memory on verbal and spatial associative tests, reported Andres M. Lozano, M.D., Ph.D., of Toronto Western Hospital, and colleagues online in the Annals of Neurology.
This single-patient case study suggested a potential new application for deep-brain stimulation in patients with disorders such as early Alzheimer’s disease, Dr. Lozano said.
Andres M. Lozano, BSc, MD, BMedSci, FRCSC, PhD is
Senior Scientist,
Division of Brain Imaging & Behaviour Systems – Neuroscience,
Toronto Western Research Institute (TWRI).
Andres is interested in understanding the causes of Parkinson’s
disease and in developing novel treatments. His experiments aim at
uncovering the mechanisms through which dopamine neurons die and
developing novel strategies to prevent their death using experiments on
models of Parkinson’s disease.
His second focus is functional neurosurgery. In these
studies he aims to improve our understanding of how disruptions in
neural
activity in the brain of human patients lead to subthalamic nucleus and
various areas of the cortex to obtain direct recordings to cellular
activity in these nuclei. These approaches help understand the
pathogenesis of these disorders and are leading the development of novel
treatment strategies.
Andres edited
Movement Disorder Surgery: Progress and Challenges (Progress in
Neurological Surgery),
coedited
Surgical Treatment of Parkinson’s Disease and Other Movement
Disorders
(Current Clinical Neurology),
and
coauthored
Bilateral deep brain stimulation of the pedunculopontine and
subthalamic
nuclei in severe Parkinson’s disease,
Posteroventral Medial Pallidotomy in Advanced Parkinson’s
Disease,
Neuropsychological consequences of chronic bilateral stimulation of
the
subthalamic nucleus in Parkinson’s disease,
Deep Brain Stimulation for Treatment-Resistant Depression,
and
Expression of the growth-associated protein GAP-43 in adult rat
retinal
ganglion cells following axon injury.
Read the
full list of his publications!
Andres is a graduate of the University of Ottawa, Faculty of Medicine
in 1983, He underwent Neurosurgical Training at McGill University. He became
a Fellow of the Royal College of Physicians and Surgeons of Canada in
1990. During his residency in Montreal, He earned his Ph.D. in
Experimental Medicine in 1989. He joined the Neurosurgical Staff
at the Toronto Western Hospital in 1991. He is currently Professor in
the Department of Surgery, and inaugural Chair Holder of the Ron Tasker
Chair in Stereotactic and Functional Neurosurgery at the University
Health Network. He also holds a Tier I Canada Research Chair in
Neuroscience.
Read
New Movement in Parkinson’s and
An INTERVIEW with Dr. Andres M. Lozano.